What is lepromatous leprosy?
Malignant, progressive form of leprosy that results from failure of cell-mediated immunity and primarily affects the nerves, skin, eyes, and testes, leading to loss of sensation in symmetric stocking-glove distribution, leonine facies (thickened facial skin), nodular skin lesions, saddle-nose deformity, blindness, and infertility. Sensory loss can lead to repetitive trauma and secondary infection, eventually leading to loss of fingers and toes. In lepromatous leprosy biopsies of lesions may show large numbers of organisms and minimal host inflammatory response.
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