What are the main toxicities of anti-tuberculous therapy?
Answer:
Rifampin → orange discoloration of urine/tears, hepatitis, drug interactions
Isoniazid → hepatitis, peripheral neuropathy, lupus-like syndrome
Pyrazinamide → hepatitis, hyperuricemia
Ethambutol → optic neuritis
Streptomycin → nephro- and ototoxicity
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